Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection

T Opriessnig, S Ramamoorthy, D M Madson, A R Patterson, N Pal, S Carman, X J Meng, P G Halbur

Research output: Contribution to journalArticlepeer-review

Abstract

Porcine circovirus type 2 (PCV2) is divided into two genetic clusters designated PCV2a and PCV2b. The objectives of this study were to determine whether isolates from different clusters vary in virulence and to determine whether infection with PCV2a isolates induces protective immunity against subsequent infection with a recent PCV2b isolate. One-hundred and thirteen conventional specific-pathogen-free (SPF) pigs were assigned randomly to treatment groups and rooms: pigs inoculated with PCV2a cluster isolates (ISU-40895 or ISU-4838), pigs inoculated with PCV2b cluster isolates (NC-16845 or Can-17639) and uninoculated pigs. Necropsies were performed at 16 or 51 days post-inoculation (p.i.). There were no significant differences in PCV2-associated lymphoid lesions between PCV2a and PCV2b clusters; however, within the same cluster, significant differences were found between isolates: ISU-4838- and Can-17639-inoculated pigs had significantly (P
Original languageEnglish
Pages (from-to)2482-91
Number of pages10
JournalJournal of General Virology
Volume89
Issue numberPt 10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Animals
  • Antibodies, Viral
  • Circoviridae Infections
  • Circovirus
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Specific Pathogen-Free Organisms
  • Swine
  • Swine Diseases
  • Virulence

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