Differential cell cycle regulation by low- and high-risk human papillomaviruses in low-grade squamous intraepithelial lesions of the cervix

S A Southern, C S Herrington

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, 11, 42, 43, and 44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, 31, 33, 39, 45, 51, 52, 56, 58, and 66). The expression of cyclins E, A, and B proteins was increased in both low-risk and high-risk HPV infections. Tetrasomy of chromosomes 1, 3, 11, 17, 18, and X was present in nine lesions, all of which were infected with high-risk HPVs, but was not related to the pattern of cyclin expression. These data provide in vivo evidence that low- and high-risk HPV types alter cell cycle control by different mechanisms and that cell cycle checkpoint abnormalities are induced by high-risk, but not low-risk, HPV infection.

Original languageEnglish
Pages (from-to)2941-5
Number of pages5
JournalCancer Research
Volume58
Issue number14
Publication statusPublished - 15 Jul 1998

Keywords

  • Cell Cycle
  • Cervical Intraepithelial Neoplasia
  • Chromosome Aberrations
  • Chromosome Disorders
  • Cyclin D1
  • Epithelium
  • Female
  • Humans
  • Papillomaviridae
  • Papillomavirus Infections
  • Tumor Virus Infections
  • Uterine Cervical Neoplasms
  • Warts

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