Differential chemosensitivity of tumor components in a malignant oligodendroglioma: assessment with diffusion-weighted, perfusion-weighted, and serial volumetric MR imaging

Hans Rolf Jäger, Adam D Waldman, Christopher Benton, Nicholas Fox, Jeremy Rees

Research output: Contribution to journalArticlepeer-review

Abstract

We report the case of malignant oligodendroglioma in a 36-year-old man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy. The tumor regions exhibiting a low apparent diffusion coefficient and increased relative cerebral blood volume showed a marked response to chemotherapy and dramatic decrease in volume, whereas the remaining tumor regions showed little change. Diffusion-weighted and perfusion-weighted MR imaging may be helpful in predicting chemosensitivity of glial tumors.

Original languageEnglish
Pages (from-to)274-8
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume26
Issue number2
Publication statusPublished - Feb 2005

Keywords

  • Adult
  • Diffusion Magnetic Resonance Imaging
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Oligodendroglioma
  • Case Reports
  • Journal Article

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