Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

L E Finlan, N M Kernohan, G Thomson, P E Beattie, T R Hupp, S H Ibbotson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)-induced skin cancer in animal models. Although p53 protein stabilization is induced after solar-simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined.
Original languageEnglish
Pages (from-to)1001-10
Number of pages10
JournalBritish journal of dermatology
Volume153
Issue number5
DOIs
Publication statusPublished - Nov 2005

Keywords / Materials (for Non-textual outputs)

  • Aminolevulinic Acid
  • Apoptosis
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • Humans
  • Keratinocytes
  • Oxidative Stress
  • PUVA Therapy
  • Phosphorylation
  • Photochemotherapy
  • Skin
  • Tumor Suppressor Protein p53

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