Abstract / Description of output
The development of neoplasia is associated with abnormalities of cell cycle control and apoptosis. In this study, a panel of cyclin-dependent kinase inhibitors (CDKIs) and apoptosis-related proteins (p16, p21, p53, Bcl2 and hsp27) was analysed by immunohistochemistry in 91 glandular cervical lesions. A significant increase in p21 and p53 expression occurred from normal cervix (n=11) through endometriosis/tubo-endometrioid metaplasia (TEM) (n=19) and cervical glandular intraepithelial neoplasia (CGIN)/adenocarcinoma in situ (AIS) (n=33) to invasive adenocarcinoma (n=28). p16 showed diffuse strong expression in CGIN/AIS and invasive adenocarcinoma compared with focal expression in some TEM/endometriosis lesions and no expression in normal cervix. Bcl2 was highly expressed in TEM/endometriosis compared with CGIN/AIS and adenocarcinoma. p16 immunostaining discriminated accurately between neoplastic and non-neoplastic cervical lesions, provided that diffuse strong positivity was present. Similarly, diffuse expression of Bcl2 distinguished endometriosis/TEM from CGIN/AIS. These data demonstrate that analysis of CDKIs and apoptosis-related proteins provides useful information in the diagnostic assessment of glandular lesions of the cervix.
Original language | English |
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Pages (from-to) | 2011-8 |
Number of pages | 8 |
Journal | European journal of cancer (Oxford, England : 1990) |
Volume | 43 |
Issue number | 13 |
DOIs | |
Publication status | Published - Sept 2007 |
Keywords / Materials (for Non-textual outputs)
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Cervical Intraepithelial Neoplasia
- Cervix Uteri
- Cyclin-Dependent Kinase Inhibitor Proteins
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Tumor Markers, Biological
- Uterine Cervical Neoplasms