Differential expression of selected histone modifier genes in human solid cancers

Hilal Ozdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas

Research output: Contribution to journalArticlepeer-review

Abstract

Post-translational modification of histones resulting in chromatin remodelling plays a key role in the regulation of gene expression. Here we report characteristic patterns of expression of 12 members of 3 classes of chromatin modifier genes in 6 different cancer types: histone acetyltransferases (HATs)- EP300, CREBBP, and PCAF; histone deacetylases (HDACs)- HDAC1, HDAC2, HDAC4, HDAC5, HDAC7A, and SIRT1; and histone methyltransferases (HMTs)- SUV39H1and SUV39H2. Expression of each gene in 225 samples (135 primary tumours, 47 cancer cell lines, and 43 normal tissues) was analysedby QRT-PCR, normalized with 8 housekeeping genes, and given as a ratio by comparison with a universal reference RNA.
Original languageEnglish
Pages (from-to)90
JournalBMC Genomics
Volume7
DOIs
Publication statusPublished - 2006

Keywords

  • Breast Neoplasms
  • Carcinoma
  • Cell Transformation, Neoplastic
  • Cluster Analysis
  • Colorectal Neoplasms
  • DNA, Complementary
  • DNA, Neoplasm
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Histone Acetyltransferases
  • Histone Code
  • Histone Deacetylases
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Humans
  • Linear Models
  • Lung Neoplasms
  • Male
  • Neoplasm Proteins
  • Neoplasms
  • Ovarian Neoplasms
  • Pancreatic Neoplasms
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Protein Methyltransferases
  • Protein Processing, Post-Translational

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