Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes

GENOMOS Study, John P A Ioannidis, Stuart H Ralston, Simon T Bennett, Maria Luisa Brandi, Daniel Grinberg, Fotini B Karassa, Bente Langdahl, Joyce B J van Meurs, Leif Mosekilde, Serena Scollen, Omar M E Albagha, Mariona Bustamante, Alisoun H Carey, Alison M Dunning, Anna Enjuanes, Johannes P T M van Leeuwen, Carmelo Mavilia, Laura Masi, Fiona E A McGuiganXavier Nogues, Huibert A P Pols, David M Reid, Stephanie C E Schuit, Rachael E Sherlock, André G Uitterlinden

Research output: Contribution to journalArticlepeer-review


Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.
Original languageEnglish
Pages (from-to)2105-14
Number of pages10
JournalJournal of the American Medical Association
Issue number17
Publication statusPublished - 3 Nov 2004


  • Aged
  • Bone Density
  • Estrogen Receptor alpha
  • Female
  • Femur Neck
  • Fractures, Bone
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Lumbar Vertebrae
  • Male
  • Meta-Analysis as Topic
  • Microsatellite Repeats
  • Middle Aged
  • Osteoporosis
  • Polymorphism, Genetic
  • Receptors, Estrogen
  • Risk

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