Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes

GENOMOS Study; John P A Ioannidis; Stuart H Ralston; Simon T Bennett; Maria Luisa Brandi; Daniel Grinberg; Fotini B Karassa; Bente Langdahl; Joyce B J van Meurs; Leif Mosekilde; Serena Scollen; Omar M E Albagha; Mariona Bustamante; Alisoun H Carey; Alison M Dunning; Anna Enjuanes; Johannes P T M van Leeuwen; Carmelo Mavilia; Laura Masi; Fiona E A McGuigan; Xavier Nogues; Huibert A P Pols; David M Reid; Stephanie C E Schuit; Rachael E Sherlock; André G Uitterlinden

doi:10.1001/jama.292.17.2105

Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes

GENOMOS Study
, John P A Ioannidis
, Stuart H Ralston
, Simon T Bennett
, Maria Luisa Brandi
, Daniel Grinberg
, Fotini B Karassa
, Bente Langdahl
, Joyce B J van Meurs
, Leif Mosekilde
, Serena Scollen
, Omar M E Albagha
, Mariona Bustamante
, Alisoun H Carey
, Alison M Dunning
, Anna Enjuanes
, Johannes P T M van Leeuwen
, Carmelo Mavilia
, Laura Masi
, Fiona E A McGuigan

Xavier Nogues, Huibert A P Pols, David M Reid, Stephanie C E Schuit, Rachael E Sherlock, André G Uitterlinden

Research output: Contribution to journal › Article › peer-review

Abstract

Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.

Original language	English
Pages (from-to)	2105-14
Number of pages	10
Journal	Journal of the American Medical Association
Volume	292
Issue number	17
DOIs	https://doi.org/10.1001/jama.292.17.2105
Publication status	Published - 3 Nov 2004

Keywords / Materials (for Non-textual outputs)

Aged
Bone Density
Estrogen Receptor alpha
Female
Femur Neck
Fractures, Bone
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Lumbar Vertebrae
Male
Meta-Analysis as Topic
Microsatellite Repeats
Middle Aged
Osteoporosis
Polymorphism, Genetic
Receptors, Estrogen
Risk

Access to Document

10.1001/jama.292.17.2105

Cite this

GENOMOS Study, Ioannidis, J. P. A., Ralston, S. H., Bennett, S. T., Brandi, M. L., Grinberg, D., Karassa, F. B., Langdahl, B., van Meurs, J. B. J., Mosekilde, L., Scollen, S., Albagha, O. M. E., Bustamante, M., Carey, A. H., Dunning, A. M., Enjuanes, A., van Leeuwen, J. P. T. M., Mavilia, C., Masi, L., ... Uitterlinden, A. G. (2004). Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. Journal of the American Medical Association, 292(17), 2105-14. https://doi.org/10.1001/jama.292.17.2105

@article{44655efe7a21485f8cf28a650a301e56,

title = "Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes",

abstract = "Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.",

keywords = "Aged, Bone Density, Estrogen Receptor alpha, Female, Femur Neck, Fractures, Bone, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Lumbar Vertebrae, Male, Meta-Analysis as Topic, Microsatellite Repeats, Middle Aged, Osteoporosis, Polymorphism, Genetic, Receptors, Estrogen, Risk",

author = "\{GENOMOS Study\} and Ioannidis, \{John P A\} and Ralston, \{Stuart H\} and Bennett, \{Simon T\} and Brandi, \{Maria Luisa\} and Daniel Grinberg and Karassa, \{Fotini B\} and Bente Langdahl and \{van Meurs\}, \{Joyce B J\} and Leif Mosekilde and Serena Scollen and Albagha, \{Omar M E\} and Mariona Bustamante and Carey, \{Alisoun H\} and Dunning, \{Alison M\} and Anna Enjuanes and \{van Leeuwen\}, \{Johannes P T M\} and Carmelo Mavilia and Laura Masi and McGuigan, \{Fiona E A\} and Xavier Nogues and Pols, \{Huibert A P\} and Reid, \{David M\} and Schuit, \{Stephanie C E\} and Sherlock, \{Rachael E\} and Uitterlinden, \{Andr{\'e} G\}",

year = "2004",

month = nov,

day = "3",

doi = "10.1001/jama.292.17.2105",

language = "English",

volume = "292",

pages = "2105--14",

journal = "Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "17",

}

GENOMOS Study, Ioannidis, JPA, Ralston, SH, Bennett, ST, Brandi, ML, Grinberg, D, Karassa, FB, Langdahl, B, van Meurs, JBJ, Mosekilde, L, Scollen, S, Albagha, OME, Bustamante, M, Carey, AH, Dunning, AM, Enjuanes, A, van Leeuwen, JPTM, Mavilia, C, Masi, L, McGuigan, FEA, Nogues, X, Pols, HAP, Reid, DM, Schuit, SCE, Sherlock, RE & Uitterlinden, AG 2004, 'Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes', Journal of the American Medical Association, vol. 292, no. 17, pp. 2105-14. https://doi.org/10.1001/jama.292.17.2105

TY - JOUR

T1 - Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes

AU - GENOMOS Study

AU - Ioannidis, John P A

AU - Ralston, Stuart H

AU - Bennett, Simon T

AU - Brandi, Maria Luisa

AU - Grinberg, Daniel

AU - Karassa, Fotini B

AU - Langdahl, Bente

AU - van Meurs, Joyce B J

AU - Mosekilde, Leif

AU - Scollen, Serena

AU - Albagha, Omar M E

AU - Bustamante, Mariona

AU - Carey, Alisoun H

AU - Dunning, Alison M

AU - Enjuanes, Anna

AU - van Leeuwen, Johannes P T M

AU - Mavilia, Carmelo

AU - Masi, Laura

AU - McGuigan, Fiona E A

AU - Nogues, Xavier

AU - Pols, Huibert A P

AU - Reid, David M

AU - Schuit, Stephanie C E

AU - Sherlock, Rachael E

AU - Uitterlinden, André G

PY - 2004/11/3

Y1 - 2004/11/3

N2 - Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.

AB - Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.

KW - Aged

KW - Bone Density

KW - Estrogen Receptor alpha

KW - Female

KW - Femur Neck

KW - Fractures, Bone

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Lumbar Vertebrae

KW - Male

KW - Meta-Analysis as Topic

KW - Microsatellite Repeats

KW - Middle Aged

KW - Osteoporosis

KW - Polymorphism, Genetic

KW - Receptors, Estrogen

KW - Risk

U2 - 10.1001/jama.292.17.2105

DO - 10.1001/jama.292.17.2105

M3 - Article

C2 - 15523071

SN - 0098-7484

VL - 292

SP - 2105

EP - 2114

JO - Journal of the American Medical Association

JF - Journal of the American Medical Association

IS - 17

ER -

Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this