Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R  Cavanagh; C  Dobano; I M  Elhassan; K  Marsh; A  Elhassan; L  Hviid; E A T G  Khalil; T G  Theander; D E  Arnot; J S  McBride; David Cavanagh

doi:10.1128/​IAI.69.2.1207-1211.2001

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R Cavanagh
, C Dobano
, I M Elhassan
, K Marsh
, A Elhassan
, L Hviid
, E A T G Khalil
, T G Theander
, D E Arnot
, J S McBride
, David Cavanagh

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

Original language	English
Pages (from-to)	1207-1211
Number of pages	5
Journal	Infection and Immunity
Volume	69
Issue number	2
DOIs	https://doi.org/10.1128/IAI.69.2.1207-1211.2001
Publication status	Published - Feb 2001

Keywords / Materials (for Non-textual outputs)

CARBOXY-TERMINAL FRAGMENT
HUMORAL IMMUNE-RESPONSES
HUMAN-ANTIBODY RESPONSE
UNSTABLE MALARIA
IGG SUBCLASSES
FC-GAMMA
ANTIGEN
INFECTIONS
REACTIVITY
PRECURSOR

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Cavanagh, D. R., Dobano, C., Elhassan, I. M., Marsh, K., Elhassan, A., Hviid, L., Khalil, E. A. T. G., Theander, T. G., Arnot, D. E., McBride, J. S., & Cavanagh, D. (2001). Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. Infection and Immunity, 69(2), 1207-1211. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

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title = "Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum",

abstract = "Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.",

keywords = "CARBOXY-TERMINAL FRAGMENT, HUMORAL IMMUNE-RESPONSES, HUMAN-ANTIBODY RESPONSE, UNSTABLE MALARIA, IGG SUBCLASSES, FC-GAMMA, ANTIGEN, INFECTIONS, REACTIVITY, PRECURSOR",

author = "Cavanagh, \{D R\} and C Dobano and Elhassan, \{I M\} and K Marsh and A Elhassan and L Hviid and Khalil, \{E A T G\} and Theander, \{T G\} and Arnot, \{D E\} and McBride, \{J S\} and David Cavanagh",

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month = feb,

doi = "10.1128/IAI.69.2.1207-1211.2001",

language = "English",

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Cavanagh, DR, Dobano, C, Elhassan, IM, Marsh, K, Elhassan, A, Hviid, L, Khalil, EATG, Theander, TG, Arnot, DE, McBride, JS & Cavanagh, D 2001, 'Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum', Infection and Immunity, vol. 69, no. 2, pp. 1207-1211. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

TY - JOUR

T1 - Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

AU - Cavanagh, D R

AU - Dobano, C

AU - Elhassan, I M

AU - Marsh, K

AU - Elhassan, A

AU - Hviid, L

AU - Khalil, E A T G

AU - Theander, T G

AU - Arnot, D E

AU - McBride, J S

AU - Cavanagh, David

PY - 2001/2

Y1 - 2001/2

N2 - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

AB - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

KW - CARBOXY-TERMINAL FRAGMENT

KW - HUMORAL IMMUNE-RESPONSES

KW - HUMAN-ANTIBODY RESPONSE

KW - UNSTABLE MALARIA

KW - IGG SUBCLASSES

KW - FC-GAMMA

KW - ANTIGEN

KW - INFECTIONS

KW - REACTIVITY

KW - PRECURSOR

U2 - 10.1128/IAI.69.2.1207-1211.2001

DO - 10.1128/IAI.69.2.1207-1211.2001

M3 - Article

SN - 0019-9567

VL - 69

SP - 1207

EP - 1211

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

Abstract

Keywords / Materials (for Non-textual outputs)

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