Differential regulation of variant glucocorticoid receptor rnRNAs in the rat hippocampus by the antidepressant fluoxetine

J L W  Yau; J  Noble; K E  Chapman; J R  Seckl

doi:10.1016/j.molbrainres.2004.06.033

Differential regulation of variant glucocorticoid receptor rnRNAs in the rat hippocampus by the antidepressant fluoxetine

J L W Yau, J Noble, K E Chapman, J R Seckl

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions. (C) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	189-192
Number of pages	4
Journal	Molecular brain research
Volume	129
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molbrainres.2004.06.033
Publication status	Published - 22 Oct 2004

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title = "Differential regulation of variant glucocorticoid receptor rnRNAs in the rat hippocampus by the antidepressant fluoxetine",

abstract = "Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions. (C) 2004 Elsevier B.V. All rights reserved.",

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AU - Seckl, J R

PY - 2004/10/22

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AB - Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions. (C) 2004 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.molbrainres.2004.06.033

DO - 10.1016/j.molbrainres.2004.06.033

M3 - Article

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JO - Molecular brain research

JF - Molecular brain research

IS - 1-2

ER -

Differential regulation of variant glucocorticoid receptor rnRNAs in the rat hippocampus by the antidepressant fluoxetine

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