Differential regulation of variant glucocorticoid receptor rnRNAs in the rat hippocampus by the antidepressant fluoxetine

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Abstract

Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions. (C) 2004 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalMolecular brain research
Volume129
Issue number1-2
DOIs
Publication statusPublished - 22 Oct 2004

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