Differential Requirements for Fgf3 and Fgf8 During Mouse Forebrain Development

T. Theil, E. Dominguez-Frutos, T. Schimmang

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Multiple Fgfs are expressed during formation and patterning of the telencephalon in vertebrates. Fgf8 has been shown to control the size of the telencephalon and the development of signaling centers in zebrafish and mouse. Next to Fgf8, Fgf3 also influences telencephalic gene expression in the zebrafish. Moreover, Fgf3 and Fgf8 have been shown to have combinatorial functions during forebrain development in this species. Here, we have examined telencephalic development in Fgf3 null mouse mutants and embryos that lack both Fgf3 and Fgf8 in their forebrain. In contrast to zebrafish, Fgf3 mutants show normal forebrain development and expression of telencephalic marker genes. Although double mutants for Fgf3 and Fgf8 show a further reduction of forebrain size no additional changes of telencephalic gene expression are observed compared with Fgf8 mutants. Therefore unlike in zebrafish, Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process.
Original languageEnglish
Pages (from-to)3417-3423
Number of pages7
JournalDevelopmental Dynamics
Volume237
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords / Materials (for Non-textual outputs)

  • telencephalon
  • fibroblast growth factor
  • conditional knockout

Fingerprint

Dive into the research topics of 'Differential Requirements for Fgf3 and Fgf8 During Mouse Forebrain Development'. Together they form a unique fingerprint.

Cite this