Direct Estimation of Pharmacokinetic Parameters from DCE-MRI using Deep CNN with Forward Physical Model Loss

Cagdas Ulas, Giles Tetteh, Michael J. Thrippleton, Paul A. Armitage, Stephen D. Makin, Joanna M. Wardlaw, Mike E. Davies, Bjoern H. Menze

Research output: Contribution to conferencePaperpeer-review


Dynamic contrast-enhanced (DCE) MRI is an evolving imaging technique that provides a quantitative measure of pharmacokinetic (PK) parameters in body tissues, in which series of T1-weighted images are collected following the administration of a paramagnetic contrast agent. Unfortunately, in many applications, conventional clinical DCE-MRI suffers from low spatiotemporal resolution and insufficient volume coverage. In this paper, we propose a novel deep learning based approach to directly estimate the PK parameters from undersampled DCE-MRI data. Specifically, we design a custom loss function where we incorporate a forward physical model that relates the PK parameters to corrupted image-time series obtained due to subsampling in k-space. This allows the network to directly exploit the knowledge of true contrast agent kinetics in the training phase, and hence provide more accurate restoration of PK parameters. Experiments on clinical brain DCE datasets demonstrate the efficacy of our approach in terms of fidelity of PK parameter reconstruction and significantly faster parameter inference compared to a model-based iterative reconstruction method.
Original languageUndefined/Unknown
Publication statusPublished - 8 Apr 2018
EventInternational Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2018 -
Duration: 16 Sep 201820 Sep 2018


ConferenceInternational Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2018
Internet address


  • cs.CV

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