Direct exploration of the role of the ventral anterior temporal lobe in semantic memory: Cortical stimulation and local field potential evidence from subdural grid electrodes

A. Shimotake, R. Matsumoto, T. Ueno, T. Kunieda, S. Saito, Paul Hoffman, T. Kikuchi, H. Fukuyama, S. Miyamoto, R. Takahashi, A. Ikeda, M. A. Lambon Ralph

Research output: Contribution to journalArticlepeer-review

Abstract

Semantic memory is a crucial higher cortical function that codes the meaning of objects and words, and when impaired after neurological damage, patients are leftwith significant disability. Investigations of semantic dementia have implicated the anterior temporal lobe (ATL) region, in general, as crucial for multimodal semanticmemory. The potentially crucial role of the ventral ATL
subregion has been emphasized by recent functional neuroimaging studies, but the necessity of this precise area has not been selectively tested. The mplantation of subdural electrode grids over this subregion, for the presurgical assessment of patients with partial epilepsy or brain tumor, offers the dual yet rare opportunities to record cortical local field potentials while participants
complete semantic tasks and to stimulate the functionally identified regions in the same participants to evaluate the necessity of these areas in semantic processing. Across 6 patients, and utilizing a variety of semantic assessments,we evaluated and confirmed that the anterior fusiform/inferior temporal gyrus is crucial in multimodal, receptive, and expressive, semantic processing.
Original languageEnglish
Pages (from-to)3802-3817
Number of pages16
JournalCerebral Cortex
Volume25
Issue number10
DOIs
Publication statusPublished - 9 Dec 2014

Keywords

  • anterior fusiform
  • basal temporal language area
  • semantic memory
  • subdural electrodes
  • ventral anterior

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