The F nucleus is one of the radioactive isotopes produced during nova explosions. It is of particular interest since it is mainly responsible for the 511 keV gamma-ray emission of novae that could be detected with the INTEGRAL satellite or future gamma-ray telescopes. The amount of 18F synthesised still suffers from large uncertainties coming from missing nuclear information concerning the 18F destruction reaction F(p,α) O. In particular, the interference sign between three 3/2+ resonances in 19Ne, situated slightly above the proton threshold (8 keV and/or 38 keV) and at higher energy (665 keV), is unknown. The maximum effect of these interferences is lying in the energy range corresponding to the Gamow peak region and has a strong impact on the F(p, α)O reaction rate. We report here on the direct measurement at low energy (down to 400 keV in the center-of-mass) of the F(p, α)O total cross section that we performed at the Louvain-la-Neuve CRC-RIB facility with the high-intensity and -purity F radioactive beam (T = 110 min). The total cross section for the different incident energies will be presented and compared to previous experimental data. Copyright owned by the author(s).