Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

S McKay; N H Griffiths; P A Butters; E B Thubron; G E Hardingham; D J A Wyllie

doi:10.1111/j.1476-5381.2011.01748.x

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

S McKay, N H Griffiths, P A Butters, E B Thubron, G E Hardingham, D J A Wyllie

Research output: Contribution to journal › Article › peer-review

Abstract

Developmental switches in NMDA receptor subunit expression have been inferred from studies of GluN2 expression levels, changes in kinetics of glutamatergic synaptic currents and sensitivity of NMDA receptor-mediated currents to selective GluN2B antagonists. Here we use TCN 213, a novel GluN2A-selective antagonist to identify the presence of this subunit in functional NMDA receptors in developing cortical neurones.

Original language	English
Pages (from-to)	924-937
Number of pages	14
Journal	British Journal of Pharmacology
Volume	166
Issue number	3
DOIs	https://doi.org/10.1111/j.1476-5381.2011.01748.x
Publication status	Published - Jun 2012

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10.1111/j.1476-5381.2011.01748.x

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist
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http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01748.x/abstract

FELLOWSHIP: Control of neuroprotection through NMDA receptor dependant regulation of antioxidant status.
Hardingham, G. (Principal Investigator)
MRC
1/10/10 → 30/11/17
Project: Research

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abstract = "Developmental switches in NMDA receptor subunit expression have been inferred from studies of GluN2 expression levels, changes in kinetics of glutamatergic synaptic currents and sensitivity of NMDA receptor-mediated currents to selective GluN2B antagonists. Here we use TCN 213, a novel GluN2A-selective antagonist to identify the presence of this subunit in functional NMDA receptors in developing cortical neurones.",

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AU - Griffiths, N H

AU - Butters, P A

AU - Thubron, E B

AU - Hardingham, G E

AU - Wyllie, D J A

PY - 2012/6

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AB - Developmental switches in NMDA receptor subunit expression have been inferred from studies of GluN2 expression levels, changes in kinetics of glutamatergic synaptic currents and sensitivity of NMDA receptor-mediated currents to selective GluN2B antagonists. Here we use TCN 213, a novel GluN2A-selective antagonist to identify the presence of this subunit in functional NMDA receptors in developing cortical neurones.

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SN - 1476-5381

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JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

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FELLOWSHIP: Control of neuroprotection through NMDA receptor dependant regulation of antioxidant status.

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