Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

S McKay, N H Griffiths, P A Butters, E B Thubron, G E Hardingham, D J A Wyllie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Developmental switches in NMDA receptor subunit expression have been inferred from studies of GluN2 expression levels, changes in kinetics of glutamatergic synaptic currents and sensitivity of NMDA receptor-mediated currents to selective GluN2B antagonists. Here we use TCN 213, a novel GluN2A-selective antagonist to identify the presence of this subunit in functional NMDA receptors in developing cortical neurones.
Original languageEnglish
Pages (from-to)924-937
Number of pages14
JournalBritish Journal of Pharmacology
Volume166
Issue number3
DOIs
Publication statusPublished - Jun 2012

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