Directional local field potentials: A tool to optimize deep brain stimulation

Gerd Tinkhauser, Alek Pogosyan, Ines Debove, Andreas Nowacki, Syed Ahmar Shah, Kathleen Seidel, Huiling Tan, John-Stuart Brittain, Katrin Petermann, Lazzaro di Biase, Markus Oertel, Claudio Pollo, Peter Brown, Michael Schuepbach

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.

OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.

METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.

RESULTS: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.

CONCLUSION: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalMovement Disorders
Volume33
Issue number1
Early online date18 Nov 2017
DOIs
Publication statusPublished - Jan 2018

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