Directional local field potentials: A tool to optimize deep brain stimulation

Gerd Tinkhauser; Alek Pogosyan; Ines Debove; Andreas Nowacki; Syed Ahmar Shah; Kathleen Seidel; Huiling Tan; John-Stuart Brittain; Katrin Petermann; Lazzaro di Biase; Markus Oertel; Claudio Pollo; Peter Brown; Michael Schuepbach

doi:10.1002/mds.27215

Directional local field potentials: A tool to optimize deep brain stimulation

Gerd Tinkhauser, Alek Pogosyan, Ines Debove, Andreas Nowacki, Syed Ahmar Shah, Kathleen Seidel, Huiling Tan, John-Stuart Brittain, Katrin Petermann, Lazzaro di Biase, Markus Oertel, Claudio Pollo, Peter Brown, Michael Schuepbach

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Abstract / Description of output

BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.

OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.

METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.

RESULTS: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.

CONCLUSION: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Movement Disorders
Volume	33
Issue number	1
Early online date	18 Nov 2017
DOIs	https://doi.org/10.1002/mds.27215
Publication status	Published - Jan 2018

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Tinkhauser_et_al-2018-Movement_DisordersFinal published version, 571 KBLicence: Creative Commons: Attribution (CC-BY)

Ahmar Shah
- Deanery of Molecular, Genetic and Population Health Sciences - Senior Research Fellow
- Usher Institute - Chancellor's Fellow
- Centre for Medical Informatics
Person: Academic: Research Active

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title = "Directional local field potentials: A tool to optimize deep brain stimulation",

abstract = "BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.RESULTS: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.CONCLUSION: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. {\textcopyright} 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

author = "Gerd Tinkhauser and Alek Pogosyan and Ines Debove and Andreas Nowacki and Shah, {Syed Ahmar} and Kathleen Seidel and Huiling Tan and John-Stuart Brittain and Katrin Petermann and {di Biase}, Lazzaro and Markus Oertel and Claudio Pollo and Peter Brown and Michael Schuepbach",

note = "{\textcopyright} 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

year = "2018",

month = jan,

doi = "10.1002/mds.27215",

language = "English",

volume = "33",

pages = "159--164",

journal = "Movement Disorders",

issn = "0885-3185",

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number = "1",

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TY - JOUR

T1 - Directional local field potentials

T2 - A tool to optimize deep brain stimulation

AU - Tinkhauser, Gerd

AU - Pogosyan, Alek

AU - Debove, Ines

AU - Nowacki, Andreas

AU - Shah, Syed Ahmar

AU - Seidel, Kathleen

AU - Tan, Huiling

AU - Brittain, John-Stuart

AU - Petermann, Katrin

AU - di Biase, Lazzaro

AU - Oertel, Markus

AU - Pollo, Claudio

AU - Brown, Peter

AU - Schuepbach, Michael

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.RESULTS: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.CONCLUSION: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.RESULTS: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.CONCLUSION: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

U2 - 10.1002/mds.27215

DO - 10.1002/mds.27215

M3 - Article

C2 - 29150884

SN - 0885-3185

VL - 33

SP - 159

EP - 164

JO - Movement Disorders

JF - Movement Disorders

IS - 1

ER -

Directional local field potentials: A tool to optimize deep brain stimulation

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