DISC1 and Huntington's disease-overlapping pathways of vulnerability to neurological disorder?

Ruth Boxall, David J. Porteous, Pippa A. Thomson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We re-annotated the interacting partners of the neuronal scaffold protein DISC1 using a knowledge-based approach that incorporated recent protein interaction data and published literature to. This revealed two highly connected networks. These networks feature cellular function and maintenance, and cell signaling. Of potentially greatest interest was the novel finding of a high degree of connectivity between the DISC1 scaffold protein, linked to psychiatric illness, and huntingtin, the protein which is mutated in Huntington's disease. The potential link between DISC1, huntingtin and their interacting partners may open new areas of research into the effects of pathway dysregulation in severe neurological disorders.
Original languageEnglish
Article numbere16263
Pages (from-to)-
Number of pages4
JournalPLoS ONE
Issue number1
Publication statusPublished - 26 Jan 2011

Keywords / Materials (for Non-textual outputs)

  • Disease Susceptibility
  • Humans
  • Huntington Disease
  • Nerve Tissue Proteins
  • Nervous System Diseases
  • Nuclear Proteins
  • Protein Binding


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