DISC1 genetics, biology and psychiatric illness

Pippa A. Thomson; Elise L.v. Malavasi; Ellen Grünewald; Dinesh C. Soares; Malgorzata Borkowska; J. Kirsty Millar

doi:10.1007/s11515-012-1254-7

DISC1 genetics, biology and psychiatric illness

Pippa A. Thomson, Elise L.v. Malavasi, Ellen Grünewald, Dinesh C. Soares, Malgorzata Borkowska, J. Kirsty Millar

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.
Keywords: DISC1, schizophrenia, depression, genetics, neural pathways

Original language	English
Pages (from-to)	1-31
Journal	Frontiers in Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/s11515-012-1254-7
Publication status	Published - 1 Feb 2013

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10.1007/s11515-012-1254-7

DISC1 genetics, biology and psychiatric illness
Published in final edited form as: Front Biol (Beijing). Feb 1, 2013; 8(1): 1–31. doi: 10.1007/s11515-012-1254-7
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http://link.springer.com/article/10.1007%2Fs11515-012-1254-7

DISC1 Complex: Neurosignalling and Genetics
Porteous, D., Millar, K. & Wyllie, D.
MRC
1/12/09 → 30/11/13
Project: Research

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title = "DISC1 genetics, biology and psychiatric illness",

abstract = "Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.Keywords: DISC1, schizophrenia, depression, genetics, neural pathways",

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AU - Thomson, Pippa A.

AU - Malavasi, Elise L.v.

AU - Grünewald, Ellen

AU - Soares, Dinesh C.

AU - Borkowska, Malgorzata

AU - Millar, J. Kirsty

N1 - Funding: Wellcome Trust [088179] Medical Research Council [G0902166(93857), G0902166]

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N2 - Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.Keywords: DISC1, schizophrenia, depression, genetics, neural pathways

AB - Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.Keywords: DISC1, schizophrenia, depression, genetics, neural pathways

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DO - 10.1007/s11515-012-1254-7

M3 - Literature review

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DISC1 genetics, biology and psychiatric illness

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DISC1 Complex: Neurosignalling and Genetics

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