Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study

UK Collaborative HIV Cohort Study Group, R J C Gilson, S-L Man, A Copas, A Rider, S Forsyth, T Hill, L Bansi, K Porter, B Gazzard, C Orkin, D Pillay, A Schwenk, M Johnson, P Easterbook, J Walsh, M Fisher, C Leen, J Anderson, C A Sabin

Research output: Contribution to journalArticlepeer-review

Abstract

Patients starting highly active antiretroviral therapy (HAART) may have a suboptimal CD4 increase despite rapid virological suppression. The frequency and the significance for patient care of this discordant response are uncertain. This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes.
Original languageEnglish
Pages (from-to)152-60
Number of pages9
JournalHIV Medicine
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Acquired Immunodeficiency Syndrome
  • Adult
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Disease Progression
  • Female
  • Great Britain
  • HIV Infections
  • HIV-1
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Time Factors
  • Treatment Outcome
  • Viral Load

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