Discovery of 42 genome-wide significant loci associated with dyslexia

23andMe Research Team, Quantitative Trait Working Group of the GenLang Consortium, Beate St Pourcain, Clyde Francks, Riccardo E Marioni, JingJing Zhao, Silvia Paracchini, Joel B Talcott, Anthony P Monaco, John F Stein, Jeffrey R. Gruen, Richard K Olson, Erik G. Willcutt, John C DeFries, Bruce F Pennington, Shelley D Smith, Margaret. J. Wright, Nicholas G. Martin, Adam Auton, Timothy C BatesSimon E Fisher, Michelle Luciano

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
Original languageEnglish
Pages (from-to)1621-1629
JournalNature Genetics
Volume54
Issue number11
Early online date20 Oct 2022
DOIs
Publication statusPublished - Nov 2022

Keywords / Materials (for Non-textual outputs)

  • genome-wide association studies

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