Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Adam D Celiz; James G W Smith; Asha K Patel; Andrew L Hook; Divya Rajamohan; Vinoj T George; Luke Flatt; Minal J Patel; Vidana C Epa; Taranjit Singh; Robert Langer; Daniel G Anderson; Nicholas D Allen; David C Hay; David A Winkler; David A Barrett; Martyn C Davies; Lorraine E Young; Chris Denning; Morgan R Alexander

doi:10.1002/adma.201501351

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Adam D Celiz, James G W Smith, Asha K Patel, Andrew L Hook, Divya Rajamohan, Vinoj T George, Luke Flatt, Minal J Patel, Vidana C Epa, Taranjit Singh, Robert Langer, Daniel G Anderson, Nicholas D Allen, David C Hay, David A Winkler, David A Barrett, Martyn C Davies, Lorraine E Young, Chris Denning, Morgan R Alexander

Research output: Contribution to journal › Article › peer-review

Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

Original language	English
Journal	Advanced Materials
Volume	27
Issue number	27
DOIs	https://doi.org/10.1002/adma.201501351
Publication status	Published - 1 Jun 2015

Keywords / Materials (for Non-textual outputs)

polymer, stem cell, differentiation

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10.1002/adma.201501351

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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http://onlinelibrary.wiley.com/doi/10.1002/adma.201501351/full

The development of 3-dimensional implantable liver organoids
Callanan, A. (Principal Investigator)
MRC
1/10/14 → 10/04/18
Project: Research
The development of 3-dimensional implantable liver organoids
Hay, D. (Principal Investigator)
MRC
1/10/14 → 10/04/18
Project: Research
A HUB FOR ENGINEERING AND EXPLOITING THE STEM CELL NICHE
Forbes, S. (Principal Investigator)
MRC
1/11/13 → 31/03/18
Project: Research

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Celiz, A. D., Smith, J. G. W., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., Flatt, L., Patel, M. J., Epa, V. C., Singh, T., Langer, R., Anderson, D. G., Allen, N. D., Hay, D. C., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L. E., Denning, C., & Alexander, M. R. (2015). Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials, 27(27). https://doi.org/10.1002/adma.201501351

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title = "Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation",

abstract = "A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.",

keywords = "polymer, stem cell, differentiation",

author = "Celiz, {Adam D} and Smith, {James G W} and Patel, {Asha K} and Hook, {Andrew L} and Divya Rajamohan and George, {Vinoj T} and Luke Flatt and Patel, {Minal J} and Epa, {Vidana C} and Taranjit Singh and Robert Langer and Anderson, {Daniel G} and Allen, {Nicholas D} and Hay, {David C} and Winkler, {David A} and Barrett, {David A} and Davies, {Martyn C} and Young, {Lorraine E} and Chris Denning and Alexander, {Morgan R}",

year = "2015",

month = jun,

day = "1",

doi = "10.1002/adma.201501351",

language = "English",

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journal = "Advanced Materials",

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Celiz, AD, Smith, JGW, Patel, AK, Hook, AL, Rajamohan, D, George, VT, Flatt, L, Patel, MJ, Epa, VC, Singh, T, Langer, R, Anderson, DG, Allen, ND, Hay, DC, Winkler, DA, Barrett, DA, Davies, MC, Young, LE, Denning, C & Alexander, MR 2015, 'Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation', Advanced Materials, vol. 27, no. 27. https://doi.org/10.1002/adma.201501351

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T1 - Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

AU - Celiz, Adam D

AU - Smith, James G W

AU - Patel, Asha K

AU - Hook, Andrew L

AU - Rajamohan, Divya

AU - George, Vinoj T

AU - Flatt, Luke

AU - Patel, Minal J

AU - Epa, Vidana C

AU - Singh, Taranjit

AU - Langer, Robert

AU - Anderson, Daniel G

AU - Allen, Nicholas D

AU - Hay, David C

AU - Winkler, David A

AU - Barrett, David A

AU - Davies, Martyn C

AU - Young, Lorraine E

AU - Denning, Chris

AU - Alexander, Morgan R

PY - 2015/6/1

Y1 - 2015/6/1

N2 - A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

AB - A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

KW - polymer, stem cell, differentiation

U2 - 10.1002/adma.201501351

DO - 10.1002/adma.201501351

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SN - 0935-9648

VL - 27

JO - Advanced Materials

JF - Advanced Materials

IS - 27

ER -

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

The development of 3-dimensional implantable liver organoids

The development of 3-dimensional implantable liver organoids

A HUB FOR ENGINEERING AND EXPLOITING THE STEM CELL NICHE

Cite this