Discovery of novel small RNAs in the quest to unravel genome complexity

Adam E Hall, Tamas Dalmay

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The different RNA populations within the cell, or the 'RNAome', form a complex and integral layer of gene regulation. In particular, small non-coding RNAs such as microRNAs have been shown to regulate as much as half of all genes expressed in mammals. The recent discovery of novel small RNAs derived from tRNAs, snoRNAs and Y RNAs, as well as the development of techniques that can reduce sequencing bias of these molecules, is slowly helping us to unveil the secrets of the genome.

Original languageEnglish
Pages (from-to)866-70
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Animals
  • Genome
  • Mammals
  • RNA

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