Discrimination between the effects of X-ray irradiation of the mouse oocyte and uterus on the induction of dominant lethals and congenital anomalies. I Embryo-transfer experiments

J D West, K M Kirk, Y Goyder, M F Lyon

Research output: Contribution to journalArticlepeer-review

Abstract

In order to test whether irradiation of the postimplantation maternal environment had any effect on the apparent induction of dominant lethals or congenital anomalies by radiation, preimplantation embryos were surgically transferred between females which had been irradiated before conception or left untreated. A high proportion of preimplantation embryos, collected from females that had been irradiated 15-21 days prior to conception with 3.6 Gy X-rays, were either arrested or developmentally retarded compared with those collected from untreated females. The transfer experiments indicate that irradiation of the uterus has no significant effect on the frequency of subsequent postimplantation mortality or on mean fetal weight. However, it remains unclear whether irradiation of the uterus contributes to the induction of congenital anomalies.

Original languageEnglish
Pages (from-to)221-30
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume149
Issue number2
Publication statusPublished - Apr 1985

Keywords

  • Animals
  • Embryo Implantation
  • Embryo Transfer
  • Embryonic and Fetal Development
  • Female
  • Fetal Growth Retardation
  • Genes, Lethal
  • Mice
  • Mutation
  • Oocytes
  • Pregnancy
  • Uterus
  • X-Rays

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