Discrimination between the effects of X-ray irradiation of the mouse oocyte and uterus on the induction of dominant lethals and congenital anomalies. II. Localised irradiation experiments

J D West, K M Kirk, Y Goyder, M F Lyon

Research output: Contribution to journalArticlepeer-review

Abstract

In order to evaluate whether irradiation of the postimplantation maternal environment contributed to the induction of postimplantation mortality or congenital anomalies, mouse ovaries were surgically exteriorised and selectively irradiated or shielded in a specially constructed apparatus. The results show that exposure of the mouse abdomen and uterus to 3.70 Gy X-rays, 15-21 days prior to conception, has no significant effect on the incidence of either postimplantation mortality or congenital anomalies. Exposure of the ovaries to 3.27 Gy X-rays during the same period, however, increased the frequency of both postimplantation mortality and congenital anomalies.

Original languageEnglish
Pages (from-to)231-8
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume149
Issue number2
Publication statusPublished - Apr 1985

Keywords

  • Animals
  • Congenital Abnormalities
  • Embryo Implantation
  • Embryonic and Fetal Development
  • Female
  • Fetal Death
  • Genes, Lethal
  • Mice
  • Oocytes
  • Ovary
  • Pregnancy
  • Uterus
  • X-Rays

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