Abstract
In order to evaluate whether irradiation of the postimplantation maternal environment contributed to the induction of postimplantation mortality or congenital anomalies, mouse ovaries were surgically exteriorised and selectively irradiated or shielded in a specially constructed apparatus. The results show that exposure of the mouse abdomen and uterus to 3.70 Gy X-rays, 15-21 days prior to conception, has no significant effect on the incidence of either postimplantation mortality or congenital anomalies. Exposure of the ovaries to 3.27 Gy X-rays during the same period, however, increased the frequency of both postimplantation mortality and congenital anomalies.
Original language | English |
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Pages (from-to) | 231-8 |
Number of pages | 8 |
Journal | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis |
Volume | 149 |
Issue number | 2 |
Publication status | Published - Apr 1985 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Congenital Abnormalities
- Embryo Implantation
- Embryonic and Fetal Development
- Female
- Fetal Death
- Genes, Lethal
- Mice
- Oocytes
- Ovary
- Pregnancy
- Uterus
- X-Rays