Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

Hong-Xiang Liu, Olga Lopatina, Chiharu Higashida, Hiroko Fujimoto, Shirin Akther, Alena Inzhutova, Mingkun Liang, Jing Zhong, Takahiro Tsuji, Toru Yoshihara, Kohei Sumi, Mizuho Ishiyama, Wen-Jie Ma, Mitsunori Ozaki, Satoshi Yagitani, Shigeru Yokoyama, Naofumi Mukaida, Takeshi Sakurai, Osamu Hori, Katsuji YoshiokaAtsushi Hirao, Yukio Kato, Katsuhiko Ishihara, Ichiro Kato, Hiroshi Okamoto, Stanislav M. Cherepanov, Alla B. Salmina, Hirokazu Hirai, Masahide Asano, David A. Brown, Isamu Nagano, Haruhiro Higashida*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Compared with the knowledge of maternal care, much less is known about the factors required for paternal parental care. Here we report that new sires of laboratory mice, though not spontaneously parental, can be induced to show maternal-like parental care (pup retrieval) using signals from dams separated from their pups. During this interaction, the maternal mates emit 38-kHz ultrasonic vocalizations to their male partners, which are equivalent to vocalizations that occur following pheromone stimulation. Without these signals or in the absence of maternal mates, the sires do not retrieve their pups within 5 min. These results show that, in mice, the maternal parent communicates to the paternal parent to encourage pup care. This new paradigm may be useful in the analysis of the parental brain during paternal care induced by interactive communication.

Original languageEnglish
Article number1346
Number of pages8
JournalNature Communications
Volume4
DOIs
Publication statusPublished - Jan 2013

Keywords

  • MICE MUS-MUSCULUS
  • ULTRASONIC VOCALIZATIONS
  • PEROMYSCUS-CALIFORNICUS
  • PARENTAL BEHAVIOR
  • FEMALE MICE
  • OXYTOCIN
  • RATS
  • VASOPRESSIN
  • MAINTENANCE
  • RODENTS

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