Disposable electrochemical printed gold chips for the analysis of acetylcholinesterase inhibition

Vladimir Dounin, Anthony J Veloso, Holger Schulze, Till T Bachmann, Kagan Kerman

Research output: Contribution to journalArticlepeer-review

Abstract

The detection of trace levels of paraoxon and carbofuran was achieved utilizing differential pulse voltammetry (DPV) on gold disposable electrochemical printed (DEP) chips. The nanostructured gold surface of the chips enables highly sensitive oxidation of the thiocholine (TCh) product even in the absence of costly surface modifications. The inhibition of AChE activity at varying insecticide concentrations was detected with low detection limits of 10 ppb (36 nM) for paraoxon and 8 ppb (18 nM) for carbofuran. Fine-tuning of the experimental conditions will allow for the application of unmodified DEP gold chips for inexpensive on-field detection of AChE inhibition by various insecticides at or below the allowable concentrations set by European and North American regulation standards.
Original languageEnglish
Pages (from-to)63-7
Number of pages5
JournalAnalytica Chimica Acta
Volume669
Issue number1-2
DOIs
Publication statusPublished - 2010

Keywords

  • Carbofuran
  • Cholinesterase Inhibitors
  • Electrochemistry
  • Gold
  • Insecticides
  • Limit of Detection
  • Nanostructures
  • Paraoxon
  • Thiocholine

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