Schizophrenia and bipolar affective disorder are common, debilitating, and poorly understood and treated disorders. Both conditions are highly heritable. Recent genetic studies have suggested that the gene disrupted in schizophrenia 1 (DISC1) is an important risk factor. DISC1 seems to have a key role in building the brain and memories by interacting with other proteins, including nuclear distribution E-like protein and phosphodiesterase 4B. Here, we review the current knowledge, highlight some key unanswered questions and propose ways forward towards a better understanding of normal and abnormal brain development and function. In the long term, this might lead to the discovery of drugs that are more efficacious and safer than currently available ones.
|Number of pages||7|
|Journal||Trends in Molecular Medicine|
|Publication status||Published - 2006|
- 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors/genetics/*metabolism Amino Acid Sequence Animals Antipsychotic Agents/pharmacology/therapeutic use Bipolar Disorder/drug therapy/*enzymology/genetics Brain/drug effects/*enzymology/growth & development Carrier Proteins/metabolism Cyclic AMP/metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 *Genetic Predisposition to Disease Humans Memory Disorders/drug therapy/*enzymology/genetics Models, Animal Molecular Sequence Data Nerve Tissue Proteins/chemistry/genetics/*metabolism Phosphodiesterase Inhibitors/pharmacology/therapeutic use Polymorphism, Single Nucleotide Protein Binding Schizophrenia/drug therapy/*enzymology/genetics