Disseminated disease due to Mycobacterium avium complex in AIDS

P J Flegg; R B Laing; C Lee; G Harris; B Watt; C L Leen; R P Brettle

Disseminated disease due to Mycobacterium avium complex in AIDS

P J Flegg, R B Laing, C Lee, G Harris, B Watt, C L Leen, R P Brettle

College of Medicine and Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confounding variables that influence survival. Disseminated MAC was diagnosed antemortem in 18% of AIDS patients, and was the AIDS-defining diagnosis in 6% of all AIDS cases. Concomitant colonization of respiratory and gastrointestinal tracts was common (61% and 48%, respectively). In 58% of cases, CD4+ counts were

Original language	English
Pages (from-to)	617-26
Number of pages	10
Journal	QJM: An International Journal of Medicine
Volume	88
Issue number	9
Publication status	Published - Sept 1995

Keywords / Materials (for Non-textual outputs)

AIDS-Related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Adult
Case-Control Studies
Disease Progression
Female
Humans
Male
Mycobacterium
Mycobacterium avium-intracellulare Infection
Retrospective Studies
Scotland
Survival Rate

Cite this

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title = "Disseminated disease due to Mycobacterium avium complex in AIDS",

abstract = "We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confounding variables that influence survival. Disseminated MAC was diagnosed antemortem in 18% of AIDS patients, and was the AIDS-defining diagnosis in 6% of all AIDS cases. Concomitant colonization of respiratory and gastrointestinal tracts was common (61% and 48%, respectively). In 58% of cases, CD4+ counts were ",

keywords = "AIDS-Related Opportunistic Infections, Acquired Immunodeficiency Syndrome, Adult, Case-Control Studies, Disease Progression, Female, Humans, Male, Mycobacterium, Mycobacterium avium-intracellulare Infection, Retrospective Studies, Scotland, Survival Rate",

author = "Flegg, {P J} and Laing, {R B} and C Lee and G Harris and B Watt and Leen, {C L} and Brettle, {R P}",

year = "1995",

month = sep,

language = "English",

volume = "88",

pages = "617--26",

journal = "QJM: An International Journal of Medicine",

issn = "1460-2725",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Disseminated disease due to Mycobacterium avium complex in AIDS

AU - Flegg, P J

AU - Laing, R B

AU - Lee, C

AU - Harris, G

AU - Watt, B

AU - Leen, C L

AU - Brettle, R P

PY - 1995/9

Y1 - 1995/9

N2 - We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confounding variables that influence survival. Disseminated MAC was diagnosed antemortem in 18% of AIDS patients, and was the AIDS-defining diagnosis in 6% of all AIDS cases. Concomitant colonization of respiratory and gastrointestinal tracts was common (61% and 48%, respectively). In 58% of cases, CD4+ counts were

AB - We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confounding variables that influence survival. Disseminated MAC was diagnosed antemortem in 18% of AIDS patients, and was the AIDS-defining diagnosis in 6% of all AIDS cases. Concomitant colonization of respiratory and gastrointestinal tracts was common (61% and 48%, respectively). In 58% of cases, CD4+ counts were

KW - AIDS-Related Opportunistic Infections

KW - Acquired Immunodeficiency Syndrome

KW - Adult

KW - Case-Control Studies

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Mycobacterium

KW - Mycobacterium avium-intracellulare Infection

KW - Retrospective Studies

KW - Scotland

KW - Survival Rate

M3 - Article

C2 - 7583075

SN - 1460-2725

VL - 88

SP - 617

EP - 626

JO - QJM: An International Journal of Medicine

JF - QJM: An International Journal of Medicine

IS - 9

ER -

Disseminated disease due to Mycobacterium avium complex in AIDS

Abstract

Keywords / Materials (for Non-textual outputs)

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