Disseminated disease due to Mycobacterium avium complex in AIDS

P J Flegg, R B Laing, C Lee, G Harris, B Watt, C L Leen, R P Brettle

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confounding variables that influence survival. Disseminated MAC was diagnosed antemortem in 18% of AIDS patients, and was the AIDS-defining diagnosis in 6% of all AIDS cases. Concomitant colonization of respiratory and gastrointestinal tracts was common (61% and 48%, respectively). In 58% of cases, CD4+ counts were
Original languageEnglish
Pages (from-to)617-26
Number of pages10
JournalQJM: An International Journal of Medicine
Issue number9
Publication statusPublished - Sept 1995

Keywords / Materials (for Non-textual outputs)

  • AIDS-Related Opportunistic Infections
  • Acquired Immunodeficiency Syndrome
  • Adult
  • Case-Control Studies
  • Disease Progression
  • Female
  • Humans
  • Male
  • Mycobacterium
  • Mycobacterium avium-intracellulare Infection
  • Retrospective Studies
  • Scotland
  • Survival Rate


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