@article{9d85c52628414f73b8573278fccbd0b8,
title = "Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation",
abstract = "Dietary potassium (K+) supplementation is associated with a blood pressure (BP) lowering effect, but not all studies agree. Here we examined the effects of short and long-term K+ supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na+) intake and molecular alterations in the kidney that may underlie BP changes. Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na+) for 7 weeks or 2 weeks with a K+-free diet. BP was highest on a K+-free/high NaCl diet. Commensurate with increased abundance and phosphorylation of the thiazide sensitive sodium-chloride-cotransporter (NCC) on the K+-free/high NaCl diet, BP returned to normal with thiazides. Three weeks of a high K+ diet (5% K+) increased BP (predominantly during night-time) independently of dietary Na+ or anion intake. Conversely, 4 days of KCl feeding reduced BP. Both feeding periods resulted in lower NCC levels, but increased levels of cleaved (active) α and γ subunits of the epithelial Na+ channel ENaC. The elevated BP after chronic K+ feeding was reduced by amiloride but not thiazide. Our results suggest that dietary K+ has an optimal threshold where it may be most effective for cardiovascular health.",
author = "Robert Little and Murali, {Sathish K.} and Poulsen, {S{\o}ren B.} and Grimm, {Paul R.} and Adrienne Assmus and Lei Cheng and Ivy, {Jessica R.} and Hoorn, {Ewout J.} and Matchkov, {Vladimir V.} and Welling, {Paul A.} and Fenton, {Robert A.}",
note = "Funding Information: We thank Tina Myhre Pedersen, Inger-Merete Paulsen, Christian Westberg (all from the Department of Biomedicine, Aarhus University) and Ingrid van den Berg (Erasmus Medical Center, the Netherlands) for technical support. We thank Cristina Esteva Font (Department of Biomedicine, Aarhus University) for slide scanning. The project was funded by the Leducq Foundation (17CVD05), the Novo Nor-disk Foundation (NNF21OC0067647, NNF17OC0029724, NNF19OC0058439), and the Independent Research Fund Denmark. Funding Information: We thank Tina Myhre Pedersen, Inger-Merete Paulsen, Christian Westberg (all from the Department of Biomedicine, Aarhus University) and Ingrid van den Berg (Erasmus Medical Center, the Netherlands) for technical support. We thank Cristina Esteva Font (Department of Biomedicine, Aarhus University) for slide scanning. The project was funded by the Leducq Foundation (17CVD05), the Novo Nordisk Foundation (NNF21OC0067647, NNF17OC0029724, NNF19OC0058439), and the Independent Research Fund Denmark. Publisher Copyright: {\textcopyright} 2023, Little et al.",
year = "2023",
month = jan,
day = "31",
doi = "10.1172/jci.insight.156437",
language = "English",
journal = " JCI Insight",
issn = "2379-3708",
publisher = "The American Society for Clinical Investigation",
}