Distinct Molecular Signature of Human Skin Langerhans Cells Denotes Critical Differences in Cutaneous Dendritic Cell Immune Regulation

Marta E Polak, Stephen M Thirdborough, Chuin Y Ung, Tim Elliott, Eugene Healy, Tom C Freeman, Michael R Ardern-Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Langerhans cells (LCs) are professional antigen presenting cells (APCs) residing in the epidermis. Despite their high potential to activate T lymphocytes, current understanding of human LC biology is limited. Genome-wide comparison of the transcriptional profiles of human skin migratory CD1a+ LCs and CD11c+ dermal dendritic cells (DDCs) demonstrated significant differences between these 'dendritic cell' types, including preferential expression of 625 genes (P
Original languageEnglish
Pages (from-to)695-703
JournalJournal of Investigative Dermatology
Volume134
Issue number3
DOIs
Publication statusPublished - 2014

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