Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

Antonio Postigo, Anna Maria Calella, Bernd Fritzsch, Marlies Knipper, David Katz, Andreas Eilers, Thomas Schimmang, Gary R Lewin, Rüdiger Klein, Liliana Minichiello

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons. The intracellular signaling pathways activated by Trk (tyrosine kinase) receptors, which in vivo promote neuronal survival and target innervation, are not well understood. Using mice with TrkB or TrkC receptors lacking the docking site for Shc adaptors (trkB(shc/shc) and trkC(shc/shc) mice), we show that TrkB and TrkC promote survival of sensory neurons mainly through Shc site-independent pathways, suggesting that these receptors use similar pathways to prevent apoptosis. In contrast, the regulation of target innervation appears different: in trkB(shc/shc) mice neurons lose target innervation, whereas in trkC(shc/shc) mice the surviving TrkC-dependent neurons maintain target innervation and function. Biochemical analysis indicates that phosphorylation at the Shc site positively regulates autophosphorylation of TrkB, but not of TrkC. Our findings show that although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms.
Original languageEnglish
Pages (from-to)633-45
Number of pages13
JournalGenes & Development
Issue number5
Publication statusPublished - 2002


Dive into the research topics of 'Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons'. Together they form a unique fingerprint.

Cite this