Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein

Claire H Sweenie, Karen J Mackenzie, Alero Rone-Orugboh, Michael Liu, Stephen M Anderton

Research output: Contribution to journalArticlepeer-review

Abstract

We have assessed the complexity in T cell recognition of the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice. Immunization with the p35-55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35-55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG.
Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalJournal of Neuroimmunology
Volume183
Issue number1-2
DOIs
Publication statusPublished - 2007

Fingerprint Dive into the research topics of 'Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein'. Together they form a unique fingerprint.

Cite this