Distinguishing functions of trypanosomatid protein kinases

Mathieu Cayla; Y. Romina Nievas; Keith R. Matthews; Jeremy C. Mottram

doi:10.1016/j.pt.2022.08.009

Distinguishing functions of trypanosomatid protein kinases

Mathieu Cayla, Y. Romina Nievas, Keith R. Matthews, Jeremy C. Mottram^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.

Original language	English
Pages (from-to)	950-961
Number of pages	12
Journal	Trends in Parasitology
Volume	38
Issue number	11
Early online date	5 Sept 2022
DOIs	https://doi.org/10.1016/j.pt.2022.08.009
Publication status	Published - 1 Nov 2022

Keywords / Materials (for Non-textual outputs)

cell cycle
differentiation
Leishmania
protein kinase
Trypanosoma

Access to Document

10.1016/j.pt.2022.08.009Licence: Creative Commons: Attribution (CC-BY)

MottramEtalTP2022DistinguishingFunctionsOfTrypanosomatidProteinkinasesFinal published version, 1.18 MBLicence: Creative Commons: Attribution (CC-BY)

1 Finished
1 Active

Quorum sensing in African trypanosomes
Matthews, K. (Principal Investigator)
UK-based charities
1/02/22 → 31/01/27
Project: Research
Environmental sensing and cell-cell communication in African trypanosomes
Matthews, K. (Principal Investigator)
UK-based charities
1/04/15 → 31/01/22
Project: Research

Cite this

@article{75c62a9751374eda940d7c298f5ce52a,

title = "Distinguishing functions of trypanosomatid protein kinases",

abstract = "Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.",

keywords = "cell cycle, differentiation, Leishmania, protein kinase, Trypanosoma",

author = "Mathieu Cayla and Nievas, {Y. Romina} and Matthews, {Keith R.} and Mottram, {Jeremy C.}",

note = "Funding Information: This work was funded by The Wellcome Trust ( 200807/Z/16/Z to J.C.M. and 221717/Z/20/Z and 103740/Z/14/Z to K.R.M.). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = nov,

day = "1",

doi = "10.1016/j.pt.2022.08.009",

language = "English",

volume = "38",

pages = "950--961",

journal = "Trends in Parasitology",

issn = "1471-4922",

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number = "11",

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TY - JOUR

T1 - Distinguishing functions of trypanosomatid protein kinases

AU - Cayla, Mathieu

AU - Nievas, Y. Romina

AU - Matthews, Keith R.

AU - Mottram, Jeremy C.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.

AB - Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.

KW - cell cycle

KW - differentiation

KW - Leishmania

KW - protein kinase

KW - Trypanosoma

U2 - 10.1016/j.pt.2022.08.009

DO - 10.1016/j.pt.2022.08.009

M3 - Review article

AN - SCOPUS:85137385143

SN - 1471-4922

VL - 38

SP - 950

EP - 961

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 11

ER -

Distinguishing functions of trypanosomatid protein kinases

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Quorum sensing in African trypanosomes

Environmental sensing and cell-cell communication in African trypanosomes

Cite this