Distinguishing Type 1 from Type 2 Myocardial Infarction Using CT Coronary Angiography

Mohammed Meah, Anda Bularga, Evangelos Tzolos, Andrew R Chapman, Marwa Daghem, John Hung, Justin Chiong, Caelan Taggart, Ryan Wereski, Alasdair Gray, Marc R Dweck, Carl Roobottom, Nick Curzen, Attila Kardos, Dirk Felmeden, Nicholas L Mills, Piotr J Slomka, David E Newby, Damini Dey, Michelle C Williams

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

PURPOSE: To determine whether quantitative plaque characterization using CT coronary angiography (CTCA) can discriminate between type 1 and type 2 myocardial infarction.

METHODS: This was a secondary analysis of two prospective studies (ClinicalTrials.gov: NCT03338504 (2014-2019) and NCT02284191 (2018-2020)) that performed blinded quantitative plaque analysis on CTCA of participants with type 1 myocardial infarction, type 2 myocardial infarction, and chest pain without myocardial infarction. Logistic regression analyses were performed to identify predictors of type 1 myocardial infarction.

RESULTS: Overall, 155 participants (mean age, 64 ± [SD] 12 years; 114 men) and 36 participants (mean age, 67 ±12 years; 19 men) had type 1 and type 2 myocardial infarction respectively, and 136 (62 ± 12 years; 78 men) had chest pain without myocardial infarction. Participants with type 1 myocardial infarction had greater total (median, 44% [IQR, 35-50%] versus 35% [29-46%]), non-calcified (39% [31-46%] versus 34% [29-40%]) and low-attenuation (4.15% [1.88-5.79%] versus 1.64% [0.89-2.28%]) plaque burdens (p
CONCLUSION: Higher coronary low-attenuation plaque burden in patients with type I myocardial infarction may help distinguish these patients from those with type 2 myocardial infarction.
Original languageEnglish
JournalRadiology: Cardiothoracic Imaging
Publication statusPublished - 27 Oct 2022


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