Distortion of patches of retinal degeneration in chimaeric mice

Estimation of the proportion of degenrate retina in rd/rd and +/+ (or +/rd) chimaeras, using a linear analysis of histological sections, suggests a considerable preponderance of the normal phenotype, while analyses based on the area of the surviving tissue suggest that the proportion of each component is similar to that in other tissues. This argues against the validity of the linear analyses used by other authors. It is suggested that cell movement occurs in the outer nuclear layer, following the degeneration of the rd/rd population, and results in a distortion of the original patches of normal cells.