Distortion of patches of retinal degeneration in chimaeric mice

J D West

Research output: Contribution to journalArticlepeer-review


Estimation of the proportion of degenrate retina in rd/rd and +/+ (or +/rd) chimaeras, using a linear analysis of histological sections, suggests a considerable preponderance of the normal phenotype, while analyses based on the area of the surviving tissue suggest that the proportion of each component is similar to that in other tissues. This argues against the validity of the linear analyses used by other authors. It is suggested that cell movement occurs in the outer nuclear layer, following the degeneration of the rd/rd population, and results in a distortion of the original patches of normal cells.

Original languageEnglish
Pages (from-to)145-9
Number of pages5
JournalJournal of embryology and experimental morphology
Issue number1
Publication statusPublished - Aug 1976


  • Animals
  • Cell Count
  • Cell Movement
  • Chimera
  • Genes, Recessive
  • Genotype
  • Mice
  • Mosaicism
  • Phenotype
  • Retina
  • Retinal Degeneration


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