Projects per year
Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on 1tness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival both by assigning the requirements of high response speed and high response accuracy to two separate input pathways and by having these pathways interact to converge on Hog1, a p38 MAP kinase. Cells with only the less accurate, re2ex-like pathway are 1tter in sudden stress, whereas cells with only the slow, more accurate pathway are 1tter in 2uctuating but increasing stress. Our results demonstrate that cellular signalling is vulnerable to trade-offs in performance, but that these trade-offs can be mitigated by assigning the opposing tasks to different signalling subnetworks. Such division of labour could function broadly within cellular signal transduction.
FingerprintDive into the research topics of 'Distributing tasks via multiple input pathways increases cellular survival in stress'. Together they form a unique fingerprint.
- 2 Finished
1/12/13 → 30/11/16
A mathematical and experimental study of feedback in the single-cell dynamics of a transcriptional network in budding yeast
1/09/11 → 31/08/14