Distribution and quantitation of lung parenchymal contractile tissue in ovine lentivirus-induced lymphoid interstitial pneumonia. Do tissue forces limit lung distensibility?

D D Collie, I Pyrah, N J Watt

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Lymphoid interstitial pneumonia (LIP) is frequently identified in sheep infected with the ovine lentivirus, maedi-visna virus (MVV). Functional consequences of this condition include a reduction in lung distensibility that cannot be explained by the density of surface forces within the lung parenchyma. A potential source of tissue forces to account for this functional deficit is the substantial parenchymal smooth muscle hyperplasia that is a feature of the lung pathology. This investigation examines the relationship between lung distensibility and the quantity and distribution of smooth muscle hyperplasia in MVV-induced LIP.
Original languageEnglish
Pages (from-to)441-7
Number of pages7
JournalLaboratory investigation
Volume73
Issue number3
Publication statusPublished - Sept 1995

Keywords / Materials (for Non-textual outputs)

  • Respiratory Function Tests
  • Animals
  • Hyperplasia
  • Pneumonia, Progressive Interstitial, of Sheep
  • Muscle, Smooth
  • Lung
  • Sheep
  • Visna-maedi virus
  • Actins
  • Female

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