Distribution of Alu and L1 repeats in human YAC recombinants

B. Arveiler, D. J. Porteous

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Evidence is accumulating that the two major families of interspersed repeated human DNA sequences, Alu and L1, are not randomly distributed. However, only limited information is available on their relative long-range distribution. We have analyzed a set of randomly selected, human Chromosome (Chr) 11-specific YAC recombinants constituting a total length of about 2 Mbp for the local and global distribution of Alu and L1 repeats: the data show a strong asymmetry in the distribution of these two repeat classes and give weight, at the long-range molecular level, to previous studies indicating their partition in the human genome; they also suggest a strong tendency for L1 repeats to cluster, with a higher proportion of full-length elements than expected.
Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalMammalian Genome
Issue number12
Publication statusPublished - 1992

Keywords / Materials (for Non-textual outputs)

  • Base Sequence Chromosomes, Fungal Chromosomes, Human, Pair 11 Cloning, Molecular DNA/genetics DNA Probes Humans Molecular Sequence Data Polymerase Chain Reaction Recombination, Genetic *Repetitive Sequences, Nucleic Acid


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