Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Claire Jenkins; Neil T Perry; Tom Cheasty; Darren J Shaw; Gad Frankel; Gordon Dougan; George J Gunn; Henry R Smith; Adrienne W Paton; James C Paton

doi:10.1128/JCM.41.4.1775-1778.2003

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Claire Jenkins, Neil T Perry, Tom Cheasty, Darren J Shaw, Gad Frankel, Gordon Dougan, George J Gunn, Henry R Smith, Adrienne W Paton, James C Paton

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P <0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

Original language	English
Pages (from-to)	1775-8
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1128/JCM.41.4.1775-1778.2003
Publication status	Published - 22 Jan 2003

Keywords / Materials (for Non-textual outputs)

Algorithms
Animals
Contact Tracing/veterinary
Disease Outbreaks/veterinary
Female
Foot-and-Mouth Disease/epidemiology
Foot-and-Mouth Disease/transmission
Great Britain/epidemiology
Swine
Swine Diseases/epidemiology
Swine Diseases/transmission

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10.1128/JCM.41.4.1775-1778.2003

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins
Copyright © 2003, American Society for Microbiology
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http://jcm.asm.org/content/41/4/1775

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title = "Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins",

abstract = "Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P <0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).",

keywords = "Algorithms, Animals, Contact Tracing/veterinary, Disease Outbreaks/veterinary, Female, Foot-and-Mouth Disease/epidemiology, Foot-and-Mouth Disease/transmission, Great Britain/epidemiology, Swine, Swine Diseases/epidemiology, Swine Diseases/transmission",

author = "Claire Jenkins and Perry, {Neil T} and Tom Cheasty and Shaw, {Darren J} and Gad Frankel and Gordon Dougan and Gunn, {George J} and Smith, {Henry R} and Paton, {Adrienne W} and Paton, {James C}",

year = "2003",

month = jan,

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doi = "10.1128/JCM.41.4.1775-1778.2003",

language = "English",

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pages = "1775--8",

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T1 - Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

AU - Jenkins, Claire

AU - Perry, Neil T

AU - Cheasty, Tom

AU - Shaw, Darren J

AU - Frankel, Gad

AU - Dougan, Gordon

AU - Gunn, George J

AU - Smith, Henry R

AU - Paton, Adrienne W

AU - Paton, James C

PY - 2003/1/22

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N2 - Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P <0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

AB - Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P <0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

KW - Algorithms

KW - Animals

KW - Contact Tracing/veterinary

KW - Disease Outbreaks/veterinary

KW - Female

KW - Foot-and-Mouth Disease/epidemiology

KW - Foot-and-Mouth Disease/transmission

KW - Great Britain/epidemiology

KW - Swine

KW - Swine Diseases/epidemiology

KW - Swine Diseases/transmission

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DO - 10.1128/JCM.41.4.1775-1778.2003

M3 - Article

C2 - 12682185

SN - 0095-1137

VL - 41

SP - 1775

EP - 1778

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 4

ER -

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this