Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Claire Jenkins, Neil T Perry, Tom Cheasty, Darren J Shaw, Gad Frankel, Gordon Dougan, George J Gunn, Henry R Smith, Adrienne W Paton, James C Paton

Research output: Contribution to journalArticlepeer-review

Abstract

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P <0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).
Original languageEnglish
Pages (from-to)1775-8
Number of pages4
JournalJournal of Clinical Microbiology
Volume41
Issue number4
DOIs
Publication statusPublished - 22 Jan 2003

Keywords

  • Algorithms
  • Animals
  • Contact Tracing/veterinary
  • Disease Outbreaks/veterinary
  • Female
  • Foot-and-Mouth Disease/epidemiology
  • Foot-and-Mouth Disease/transmission
  • Great Britain/epidemiology
  • Swine
  • Swine Diseases/epidemiology
  • Swine Diseases/transmission

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