Divergent RNA transcription: A role in promoter unwinding?

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance.
Original languageEnglish
Issue number4
Publication statusPublished - 1 Jul 2013

Keywords / Materials (for Non-textual outputs)

  • Chromatin
  • Supercoiling
  • DNA
  • Anti-sense RNA


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