Diverse functions of pericytes in cerebral blood flow regulation and ischemia

Francisco Fernández-Klett, Josef Priller

Research output: Contribution to journalReview articlepeer-review

Abstract

Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity ('functional hyperemia'). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.

Original languageEnglish
Pages (from-to)883-7
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number6
Early online date8 Apr 2015
DOIs
Publication statusE-pub ahead of print - 8 Apr 2015

Keywords

  • Animals
  • Brain
  • Brain Ischemia
  • Cerebrovascular Circulation
  • Humans
  • Pericytes
  • Journal Article
  • Review

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