Abstract / Description of output
Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity ('functional hyperemia'). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.
Original language | English |
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Pages (from-to) | 883-7 |
Number of pages | 5 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 35 |
Issue number | 6 |
Early online date | 8 Apr 2015 |
DOIs | |
Publication status | E-pub ahead of print - 8 Apr 2015 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Brain
- Brain Ischemia
- Cerebrovascular Circulation
- Humans
- Pericytes
- Journal Article
- Review