Diversity-oriented optical imaging probe development

Jun-Seok Lee, Marc Vendrell, Young-Tae Chang*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

Original languageEnglish
Pages (from-to)760-767
Number of pages8
JournalCurrent opinion in chemical biology
Volume15
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • VIVO CANCER-DETECTION
  • IN-VIVO
  • FLUORESCENT-PROBES
  • COMBINATORIAL DISCOVERY
  • CORE SKELETON
  • CELL BIOLOGY
  • QUANTUM DOTS
  • PROTEIN
  • LIBRARY
  • SENSORS

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