Diversity-oriented optical imaging probe development

Jun-Seok Lee; Marc Vendrell; Young-Tae Chang

doi:10.1016/j.cbpa.2011.10.007

Diversity-oriented optical imaging probe development

Jun-Seok Lee, Marc Vendrell, Young-Tae Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

Original language	English
Pages (from-to)	760-767
Number of pages	8
Journal	Current opinion in chemical biology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.cbpa.2011.10.007
Publication status	Published - Dec 2011

Keywords / Materials (for Non-textual outputs)

VIVO CANCER-DETECTION
IN-VIVO
FLUORESCENT-PROBES
COMBINATORIAL DISCOVERY
CORE SKELETON
CELL BIOLOGY
QUANTUM DOTS
PROTEIN
LIBRARY
SENSORS

Access to Document

10.1016/j.cbpa.2011.10.007

Cite this

@article{9871e888d0c04c899fd4a2c8ddf3cd3b,

title = "Diversity-oriented optical imaging probe development",

abstract = "The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.",

keywords = "VIVO CANCER-DETECTION, IN-VIVO, FLUORESCENT-PROBES, COMBINATORIAL DISCOVERY, CORE SKELETON, CELL BIOLOGY, QUANTUM DOTS, PROTEIN, LIBRARY, SENSORS",

author = "Jun-Seok Lee and Marc Vendrell and Young-Tae Chang",

year = "2011",

month = dec,

doi = "10.1016/j.cbpa.2011.10.007",

language = "English",

volume = "15",

pages = "760--767",

journal = "Current opinion in chemical biology",

issn = "1367-5931",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Diversity-oriented optical imaging probe development

AU - Lee, Jun-Seok

AU - Vendrell, Marc

AU - Chang, Young-Tae

PY - 2011/12

Y1 - 2011/12

N2 - The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

AB - The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.

KW - VIVO CANCER-DETECTION

KW - IN-VIVO

KW - FLUORESCENT-PROBES

KW - COMBINATORIAL DISCOVERY

KW - CORE SKELETON

KW - CELL BIOLOGY

KW - QUANTUM DOTS

KW - PROTEIN

KW - LIBRARY

KW - SENSORS

U2 - 10.1016/j.cbpa.2011.10.007

DO - 10.1016/j.cbpa.2011.10.007

M3 - Literature review

SN - 1367-5931

VL - 15

SP - 760

EP - 767

JO - Current opinion in chemical biology

JF - Current opinion in chemical biology

IS - 6

ER -

Diversity-oriented optical imaging probe development

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this