DNA chisel, a versatile sequence optimizer

Valentin Zulkower, Susan J Rosser

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Motivation: Accounting for biological and practical requirements in DNA sequence design often results in challenging optimization problems. Current software solutions are problem-specific and hard to combine.Results: DNA Chisel is an easy-to-use, easy-to-extend sequence optimization framework allowing to freely define and combine optimization specifications via Python scripts or Genbank annotations.Availability: The framework is available as a web application (https://cuba.genomefoundry.org/sculpt_a_sequence)or open-source Python library (see at https://github.com/Edinburgh-Genome-Foundry/DNAChisel for code and documentation).
Original languageEnglish
Article numberbtaa558
Publication statusPublished - 9 Jul 2020


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