DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes

Anna Maria Sole  Giordano; Marco  Luciani; Francesca Gatto; Monah Abou   Alezz; Chiara  Beghè; Lucrezia della  Volpe; Alessandro  Migliara; Sara  Valsoni; Marco  Genua; Monika Dzieciatkowska; Giacomo  Frati; Julie Tahraoui-Bories; Silvia Giliani; Simona Orcesi; Elisa Fazzi; Renato Ostuni; Angelo D'Alessandro; Raffaella Di Micco; Ivan Merelli; Angelo  Lombardo; Martin A M  Reijns; Natalia Gromak; Angela  Gritti; Anna Kajaste-Rudnitski

doi:10.1084/jem.20211121

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes

Anna Maria Sole Giordano, Marco Luciani, Francesca Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia della Volpe, Alessandro Migliara, Sara Valsoni, Marco Genua, Monika Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, Silvia Giliani, Simona Orcesi, Elisa Fazzi, Renato Ostuni, Angelo D'Alessandro, Raffaella Di Micco, Ivan Merelli, Angelo LombardoMartin A M Reijns, Natalia Gromak, Angela Gritti, Anna Kajaste-Rudnitski

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of Experimental Medicine
Early online date	9 Mar 2022
DOIs	https://doi.org/10.1084/jem.20211121
Publication status	E-pub ahead of print - 9 Mar 2022

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10.1084/jem.20211121Licence: Creative Commons: Attribution (CC-BY)

jem_20211121Final published version, 7.79 MBLicence: Creative Commons: Attribution (CC-BY)

MC_UU_00007/5 From Microcephaly to Genome Stability, Inflammation and Growth Regulation
Jackson, A.
1/04/18 → 31/03/23
Project: Research

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Giordano, A. M. S., Luciani, M., Gatto, F., Alezz, M. A., Beghè, C., Volpe, L. D., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., Frati, G., Tahraoui-Bories, J., Giliani, S., Orcesi, S., Fazzi, E., Ostuni, R., D'Alessandro, A., Di Micco, R., Merelli, I., ... Kajaste-Rudnitski, A. (2022). DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes. Journal of Experimental Medicine. https://doi.org/10.1084/jem.20211121

@article{f905c0ada58341eeb773ef3151aa32fa,

title = "DNA damage contributes to neurotoxic inflammation in Aicardi-Gouti{\`e}res Syndrome astrocytes",

author = "Giordano, {Anna Maria Sole} and Marco Luciani and Francesca Gatto and Alezz, {Monah Abou} and Chiara Begh{\`e} and Volpe, {Lucrezia della} and Alessandro Migliara and Sara Valsoni and Marco Genua and Monika Dzieciatkowska and Giacomo Frati and Julie Tahraoui-Bories and Silvia Giliani and Simona Orcesi and Elisa Fazzi and Renato Ostuni and Angelo D'Alessandro and {Di Micco}, Raffaella and Ivan Merelli and Angelo Lombardo and Reijns, {Martin A M} and Natalia Gromak and Angela Gritti and Anna Kajaste-Rudnitski",

note = "Funding Information: This work was supported by the Italian Telethon Foundation to A. Kajaste-Rudnitski, R. Di Micco, and A. Gritti. R. Di Micco is a New York Stem Cell Foundation Robertson Investigator. A.M.S. Giordano, M. Luciani, A. Migliara, and L. della Volpe conducted this study as partial fulfillment of their PhD in Molecular Medicine, Program in Cellular and Molecular Biology, International PhD School, Vita-Salute San Raffaele University, Milan, Italy. The Gromak lab is supported by a Royal Society University Research fellowship (UF150656) and Enhancement Award (RGF\EA\180023) to N. Gromak. M.A.M. Reijns is supported by a Medical Research Council Human Genetics Unit core grant (MC_UU_00007/5) to Andrew P. Jackson. Publisher Copyright: {\textcopyright} 2022 Giordano et al.",

year = "2022",

month = mar,

day = "9",

doi = "10.1084/jem.20211121",

language = "English",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "ROCKEFELLER UNIV PRESS",

}

Giordano, AMS, Luciani, M, Gatto, F, Alezz, MA, Beghè, C, Volpe, LD, Migliara, A, Valsoni, S, Genua, M, Dzieciatkowska, M, Frati, G, Tahraoui-Bories, J, Giliani, S, Orcesi, S, Fazzi, E, Ostuni, R, D'Alessandro, A, Di Micco, R, Merelli, I, Lombardo, A, Reijns, MAM, Gromak, N, Gritti, A & Kajaste-Rudnitski, A 2022, 'DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes', Journal of Experimental Medicine. https://doi.org/10.1084/jem.20211121

TY - JOUR

T1 - DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes

AU - Giordano, Anna Maria Sole

AU - Luciani, Marco

AU - Gatto, Francesca

AU - Alezz, Monah Abou

AU - Beghè, Chiara

AU - Volpe, Lucrezia della

AU - Migliara, Alessandro

AU - Valsoni, Sara

AU - Genua, Marco

AU - Dzieciatkowska, Monika

AU - Frati, Giacomo

AU - Tahraoui-Bories, Julie

AU - Giliani, Silvia

AU - Orcesi, Simona

AU - Fazzi, Elisa

AU - Ostuni, Renato

AU - D'Alessandro, Angelo

AU - Di Micco, Raffaella

AU - Merelli, Ivan

AU - Lombardo, Angelo

AU - Reijns, Martin A M

AU - Gromak, Natalia

AU - Gritti, Angela

AU - Kajaste-Rudnitski, Anna

N1 - Funding Information: This work was supported by the Italian Telethon Foundation to A. Kajaste-Rudnitski, R. Di Micco, and A. Gritti. R. Di Micco is a New York Stem Cell Foundation Robertson Investigator. A.M.S. Giordano, M. Luciani, A. Migliara, and L. della Volpe conducted this study as partial fulfillment of their PhD in Molecular Medicine, Program in Cellular and Molecular Biology, International PhD School, Vita-Salute San Raffaele University, Milan, Italy. The Gromak lab is supported by a Royal Society University Research fellowship (UF150656) and Enhancement Award (RGF\EA\180023) to N. Gromak. M.A.M. Reijns is supported by a Medical Research Council Human Genetics Unit core grant (MC_UU_00007/5) to Andrew P. Jackson. Publisher Copyright: © 2022 Giordano et al.

PY - 2022/3/9

Y1 - 2022/3/9

U2 - 10.1084/jem.20211121

DO - 10.1084/jem.20211121

M3 - Article

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

ER -

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes

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Projects

MC_UU_00007/5 From Microcephaly to Genome Stability, Inflammation and Growth Regulation

Cite this