DNA Electrophoresis: Historical and Theoretical Perspectives

Gareth A. Roberts, David T. F. Dryden

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Abstract

The technique of gel electrophoresis is now firmly established as a routine laboratory method for analyzing DNA. Here, we describe the development of the methodology as well as a brief explanation of how the technique works. There is a short introduction to pulsed-field agarose gel electrophoresis, which represents a critical advancement in the method that facilitates the analysis of very large fragments of DNA. Finally, theoretical considerations are included.
Original languageEnglish
Title of host publicationDNA Electrophoresis
Subtitle of host publicationMethods and Protocols
EditorsSvetlana Makovets
PublisherHumana Press
Pages1-9
ISBN (Electronic)978-1-62703-565-1
ISBN (Print)978-1-62703-564-4
DOIs
Publication statusPublished - 17 Jul 2013

Publication series

NameDNA Electrophoresis
Volume1054
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Electrophoresis
  • DNA separation
  • Agarose
  • Polyacrylamide
  • Pulsed-field
  • Reptation

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