DNA methylation and control of gene expression in vertebrate development

R R Meehan, I Stancheva

Research output: Contribution to journalArticlepeer-review

Abstract

MeCpGs act as ligands for nuclear factors (repressors) that are components of chromatin modification and remodelling activities. The DNA-methylation-mediated repression system (Dnmt1s, MeCPs and MBDs) is highly conserved in vertebrates. DNA methylation is essential for normal vertebrate development. It is possible (but remains unproven) that the role of DNA methylation in regulating development is highly conserved in vertebrates. In mammals, DNA methylation has an additional role in regulating the expression of imprinted genes and in controlling X-inactivation.
Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalEssays in biochemistry
Volume37
Publication statusPublished - 2001

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