DNA methylation as a genomic marker of exposure to chemical and environmental agents

Richard R Meehan, John P Thomson, Antonio Lentini, Colm E Nestor, Sari Pennings

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

Original languageEnglish
Pages (from-to)48-56
Number of pages9
JournalCurrent opinion in chemical biology
Volume45
Early online date2 Mar 2018
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Animals
  • DNA Methylation/drug effects
  • Environmental Exposure/adverse effects
  • Environmental Pollutants/adverse effects
  • Epigenesis, Genetic/drug effects
  • Epigenomics/methods
  • Humans

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