DNA methylation as a genomic marker of exposure to chemical and environmental agents

Richard R Meehan; John P Thomson; Antonio Lentini; Colm E Nestor; Sari Pennings

doi:10.1016/j.cbpa.2018.02.006

DNA methylation as a genomic marker of exposure to chemical and environmental agents

Richard R Meehan, John P Thomson, Antonio Lentini, Colm E Nestor, Sari Pennings

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

Original language	English
Pages (from-to)	48-56
Number of pages	9
Journal	Current opinion in chemical biology
Volume	45
Early online date	2 Mar 2018
DOIs	https://doi.org/10.1016/j.cbpa.2018.02.006 https://doi.org/10.1016/j.cbpa.2018.02.006
Publication status	Published - Aug 2018

Keywords / Materials (for Non-textual outputs)

Animals
DNA Methylation/drug effects
Environmental Exposure/adverse effects
Environmental Pollutants/adverse effects
Epigenesis, Genetic/drug effects
Epigenomics/methods
Humans

Access to Document

1-s2.0-S1367593117302065-mainFinal published version, 1.52 MB

Epigenetic Landscape Global Nuclear Positioning Tools
Pennings, S. & Meehan, R.
BBSRC
1/07/13 → 30/06/14
Project: Research
S/SHIP - Ms Christina Aguilar
Bailey, M.
UK-based charities
1/10/10 → 30/09/14
Project: Research

Sari Pennings
- Sari.Penningsed.acuk
- Deanery of Clinical Sciences - Reader
- Centre for Cardiovascular Science
Person: Academic: Research Active

Cite this

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title = "DNA methylation as a genomic marker of exposure to chemical and environmental agents",

abstract = "Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.",

keywords = "Animals, DNA Methylation/drug effects, Environmental Exposure/adverse effects, Environmental Pollutants/adverse effects, Epigenesis, Genetic/drug effects, Epigenomics/methods, Humans",

author = "Meehan, {Richard R} and Thomson, {John P} and Antonio Lentini and Nestor, {Colm E} and Sari Pennings",

year = "2018",

month = aug,

doi = "10.1016/j.cbpa.2018.02.006",

language = "English",

volume = "45",

pages = "48--56",

journal = "Current opinion in chemical biology",

issn = "1367-5931",

publisher = "Elsevier",

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TY - JOUR

T1 - DNA methylation as a genomic marker of exposure to chemical and environmental agents

AU - Meehan, Richard R

AU - Thomson, John P

AU - Lentini, Antonio

AU - Nestor, Colm E

AU - Pennings, Sari

PY - 2018/8

Y1 - 2018/8

N2 - Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

AB - Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

KW - Animals

KW - DNA Methylation/drug effects

KW - Environmental Exposure/adverse effects

KW - Environmental Pollutants/adverse effects

KW - Epigenesis, Genetic/drug effects

KW - Epigenomics/methods

KW - Humans

U2 - 10.1016/j.cbpa.2018.02.006

DO - 10.1016/j.cbpa.2018.02.006

M3 - Review article

C2 - 29505975

SN - 1367-5931

VL - 45

SP - 48

EP - 56

JO - Current opinion in chemical biology

JF - Current opinion in chemical biology

ER -

DNA methylation as a genomic marker of exposure to chemical and environmental agents

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Epigenetic Landscape Global Nuclear Positioning Tools

S/SHIP - Ms Christina Aguilar

Profiles

Sari Pennings

Cite this