Projects per year
Abstract / Description of output
DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into epigenetic aging signatures to estimate donor age. It has been demonstrated that the difference between such epigenetic age-predictions and chronological age is indicative for of all-cause mortality in later life. In this study, we tested alternative epigenetic signatures and followed the hypothesis that even individual age-associated CpG sites might be indicative for life-expectancy. Using a 99-CpG aging model, a five-year higher age-prediction was associated with 11% greater mortality risk in DNAm profiles of the Lothian Birth Cohort 1921 study. However, models based on three CpGs, or even individual CpGs, generally revealed very high offsets in age-predictions if applied to independent microarray datasets. On the other hand, we demonstrate that DNAm levels at several individual age-associated CpGs seem to be associated with life expectancy - e.g., at CpGs associated with the genesPDE4C and CLCN6. Our results support the notion that small aging signatures should rather be analysed by more quantitative methods, such as site-specific pyrosequencing, as the precision of age-predictions is rather low on independent microarray datasets. Nevertheless, the results hold the perspective that simple epigenetic biomarkers, based on few or individual age-associated CpGs, could assist the estimation of biological age.
Original language | English |
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Pages (from-to) | 394-401 |
Number of pages | 8 |
Journal | Aging |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - 25 Feb 2016 |
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Dive into the research topics of 'DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy'. Together they form a unique fingerprint.Projects
- 7 Finished
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RA2664 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2 KNOWLEDGE EXCHANGE BUDGET
Deary, I., Maclullich, A., Porteous, D., Seckl, J. & Wardlaw, J.
1/09/13 → 31/08/19
Project: Research
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
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RA2662 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Porteous, D.
1/09/13 → 31/08/19
Project: Research