DNA methylation, nucleosome formation and positioning

Sari Pennings, James Allan, Colin S Davey

Research output: Contribution to journalArticlepeer-review


Recent mapping of nucleosome positioning on several long gene regions subject to DNA methylation has identified instances of nucleosome repositioning by this base modification. The evidence for an effect of CpG methylation on nucleosome formation and positioning in chromatin is reviewed here in the context of the complex sequence-structure requirements of DNA wrapping around the histone octamer and the role of this epigenetic mark in gene repression.
Original languageEnglish
Pages (from-to)351-61
Number of pages11
JournalBriefings in functional genomics & proteomics
Issue number4
Publication statusPublished - 2005


Dive into the research topics of 'DNA methylation, nucleosome formation and positioning'. Together they form a unique fingerprint.

Cite this