DNA methylation rates scale with maximum lifespan across mammals

Sam Crofts, Eric Latorre Crespo*, Tamir Chandra*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been observed. We developed a statistically robust framework to compare methylation rates at conserved age-related sites across mammals. We found that methylation rates negatively scale with maximum lifespan in both blood and skin. The emergence of explicit scaling suggests that methylation rates are - or are linked to - an evolutionary constraint on maximum lifespan acting across diverse mammalian lineages
Original languageEnglish
JournalNature Aging
DOIs
Publication statusPublished - 4 Dec 2023

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