@article{2873c6dd76864698ad08dba6477ad5b1,
title = "DNA methylation rates scale with maximum lifespan across mammals",
abstract = "DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been observed. We developed a statistically robust framework to compare methylation rates at conserved age-related sites across mammals. We found that methylation rates negatively scale with maximum lifespan in both blood and skin. The emergence of explicit scaling suggests that methylation rates are - or are linked to - an evolutionary constraint on maximum lifespan acting across diverse mammalian lineages",
author = "Sam Crofts and {Latorre Crespo}, Eric and Tamir Chandra",
note = "Funding Information: We thank T. Little for critical reading of the manuscript and M. D{\"o}nerta{\c s} for bringing our attention to additional statistical considerations. We thank all members of the Chandra laboratory for their input. S.J.C.C. is supported by the Wellcome Trust Hosts, Pathogens and Global Health Programme (grant number grant.226831/Z/22/Z). E.L.-C. is a cross-disciplinary postdoctoral fellow supported by funding from the University of Edinburgh and the Medical Research Council (MC_UU_00009/2). T.C. is supported through a Chancellor{\textquoteright}s Fellow award at the University of Edinburgh and the MRC Human Genetics Unit. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
day = "4",
doi = "10.1038/s43587-023-00535-6",
language = "English",
journal = "Nature Aging",
issn = "2662-8465",
publisher = "Springer Nature",
}